Anafranil (Clomipramine Hydrochloride)

Anafranil Review

Clomipramine is used to treat patients with obsessive-compulsive disorder.Clomipramine is a tricyclic agent with both antidepressant and antiobsessional properties.

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Anafranil Drug Class and Mechanism

Clomipramine (CMI) is presumed to influence obsessive and compulsive behaviors through its effects on serotonergic neuronal transmission. The actual neurochemical mechanism is unknown, but CMI's capacity to inhibit the reuptake of serotonin (5-HT) is thought to be important.

Anafranil Uses

Like other tricyclics, Clomipramine inhibits norepinephrine and serotonin uptake into central nerve terminals, possibly by blocking the membrane-pump of neurons, thereby increasing the concentration of transmitter monoamines at receptor sites. Clomipramine is presumed to influence depression and obsessive and compulsive behaviour through its effects on serotonergic neurotransmission. The actual neurochemical mechanism is unknown, but Clomipramine capacity to inhibit serotonin reuptake is thought to be important. Clomipramine appears to have a mild sedative effect which may be helpful in alleviating the anxiety component often accompanying depression. Initial doses are usually 25 mg 2 or 3 times daily or 75 mg once daily in slow released form. The dose may be increased in regular intervals (the usual dose per day is 100 to 225 mg). Doses up to 300 mg may be used, but these are associated with an increased risk of seizures. This medication may be taken with food to prevent stomach upset. In hospitalized patients initial intramuscular injections and very slow intravenous infusions can be used, but the risk of hypotension and seizures may be increased with parenteral drug use. The advantage is that the onset of action may be faster. Usually, clomipramine needs some weeks to reach its maximum effects and needs to be given as longterm treatment, sometimes for life (narcolepsy). Sometimes, in patients with narcolepsy the full effect of clomipramine is not sufficient. In these cases treatment with clomipramine should be terminated gradually and a commonly used central stimulant (e.g. modafinil, methylphenidate or methamphetamine) tried instead.

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Anafranil Side Effects

Although Anafranil 10mg Side effects from Clomipramine are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

drowsiness
dry mouth
upset stomach
vomiting
diarrhea
constipation
nervousness
decreased sexual ability
decreased memory or concentration
headache
stuffy nose
change in appetite or weight
If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

tremor
seizures
fast, irregular, or pounding heartbeat
difficulty urinating or loss of bladder control
depression
delusions or hallucinations
eye pain
shakiness
difficulty breathing or fast breathing
severe muscle stiffness
unusual tiredness or weakness

Anafranil Pregnancy

Anafranil Overdose

Deaths may occur from overdosage with this class of drugs. Multiple drug ingestion (including alcohol) is common in deliberate tricyclic overdose. As the management is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity develop rapidly after tricyclic overdose. Therefore, hospital monitoring is required as soon as possible.

Anafranil More Information

Read the Medication Guide that comes with you or your family member's antidepressant medicine. This Medication Guide is only about the risk of suicidal thoughts and actions with antidepressant medicines. Talk to your, or your family member's, healthcare provider about: all risks and benefits of treatment with antidepressant medicines all treatment choices for depression or other serious mental illness